Current Research in Medical Sciences

en Association Between Influenza-like Illness and Acute Myocardial Infarction: A Case-control Study بیماری های عفونی بیماری های عفونی پژوهشی اصیل Original Article Background: Acute myocardial infarction (AMI) is a leading cause of death worldwide. Seasonal influenza can lead to cardiovascular complications. Thus, the association between influenza and cardiovascular events has recently attracted considerable interest. This study aimed to investigate recent influenza-like illness (ILI) among AMI patients compared with other hospitalized patients (control group) during the cold season in northern Iran. Methods: This retrospective case-control study included 300 patients (150 AMI patients and 150 controls) aged ≥ 50 years who were hospitalized for AMI or other conditions between September 22, 2019, and March 15, 2020. Patients in each group were frequency-matched for gender and age range. The primary exposure was recent ILI (fever ≥ 37.8°C, cough, and sore throat) during the past month. Results: Fifty-two females with a mean age of 40.23 ± 16.31 years were included. The mean hemoglobin level before treatment was 12.40 ± 1.08 g/dL, increasing to 13.04 ± 1.04 g/dL after treatment (p < 0.001). The mean serum ferritin level increased from 27.51 μg/L before treatment to 51.81 μg/L after treatment (p < 0.001). Hemoglobin increments were also observed in two subgroups: those with ferritin levels of 15–30 μg/L (p < 0.001) and those with levels of 30–50 μg/L (p = 0.001). Conclusion: The patients’ mean age was 64.42 ± 9.47 years, ranging from 50 to 94 years. Overall, 150 (50%) patients reported ILI, with a significantly higher prevalence in the AMI group (111 cases, 74%) than in controls (39 cases, 26%). Patients in the AMI group reported ILI significantly more often than controls (adjusted OR: 3.04, 95% CI: 1.02-9.09, p < 0.001). On the other hand, patients who received the influenza vaccine were significantly less likely to have an acute myocardial infarction than those who did not (adjusted OR: 0.02, 95% CI: 0.001-0.38, p = 0.006). Influenza-like disease, Acute myocardial infarction, Vaccination, Cardiovascular diseases 30 37 http://crms.mubabol.ac.ir/browse.php?a_code=A-10-278-1&slc_lang=en&sid=1 Seyed Morteza Mohseni m.mohsene@gmali.com 10031947532846002889 10031947532846002889 No Soheil Ebrahimpour drsoheil1503@yahoo.com 10031947532846002890 10031947532846002890 No Mohammad Barary m.barary@sbmu.ac.ir 10031947532846002891 10031947532846002891 No Ghasem Faghanzadeh Ganji ghf.ganji@yahoo.com 10031947532846002892 10031947532846002892 No Arefeh Babazadeh drbabazadeh.a@yahoo.com 10031947532846002893 10031947532846002893 No Kamyar Amin persicakamyar@yahoo.com 10031947532846002894 10031947532846002894 No Ali Tavakoli Pirzaman alitavakolipirzaman@gmail.com 10031947532846002895 10031947532846002895 No Malihe Esmailzadeh Esmailzadeh@gmali.com 10031947532846002896 10031947532846002896 No Hossein Nazari Rostami m1377b@gmail.com 10031947532846002897 10031947532846002897 No Mehran Shokri mh.shokri90@gmail.com 10031947532846002898 10031947532846002898 Yes Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran