en داخلی ( گوارش ) داخلی ( گوارش ) پژوهشی اصیل Original Article Abstract<br> Background: Nowadays obesity is one of the major health problems worldwide,<br> leading many obese patients to undergo surgical intervention. Laparoscopic sleeve<br> gastrectomy (LSG) is a common approach for surgical management of morbid obesity.<br> Gallbladder stones are a common side effect of sudden weight loss after bariatric<br> surgery. The aim of this study was to investigate the relationship between weight loss<br> and gallstones and the need for prophylactic cholecystectomy.<br> Methods: This cross-sectional study was conducted on all patients who had undergone<br> gastric sleeve surgery in Babol University of Medical Sciences hospitals during 2013-<br> 2017. Demographic data such as gender, age, weight, and BMI were collected with<br> informed consent via a questionnaire. Patients were followed up over an 18-month<br> period by ultrasound and by a visit from the surgeon. The incidence of gallstones and<br> gallbladder sludge and the need for cholecystectomy were studied.<br> Results: In this study, 114 patients including 94 females and 20 males with a mean age<br> of 37.4&plusmn;8.29 years and mean weight of 142.23&plusmn;10.29 kg underwent LSG. The<br> incidence of asymptomatic and symptomatic gallstones was 23% (26/114) and 7%<br> (8/114), respectively. An apparent relationship was observed between weight loss and<br> the incidence of gallstones during the follow-up periods, except for the first month.<br> Moreover, ursodeoxycholic acid administration reduced significantly the incidence of<br> gallbladder sludge and stones (p<0.001).<br> Conclusion: The results suggest that the formation of gallstones during the period of<br> weight loss is related to the amount or rate of weight loss in the postoperative period. Sleeve gastrectomy, Obesity, Gallstone, Gallbladder sludge 34 39 http://crms.mubabol.ac.ir/browse.php?a_code=A-10-211-1&slc_lang=en&sid=1 Ali Zahedian alizahed20@yahoo.com 10031947532846002270 10031947532846002270 No Department of surgery, School of Medicine, Babol University of Medical Sciences, Babol, Iran Soraya Khafri khafri@yahoo.com 10031947532846002271 10031947532846002271 No 2Department of Epidemiology and Biostatistics, School of Public Health, Babol University of Medical Sciences, Babol, Iran Nasrin Tamaskani nsm.hafezi@gmail.com 10031947532846002272 10031947532846002272 No 3Student Committee Research, Babol University of Medical Sciences, Babol, Iran abolhasan alijanpoor alijanpourabolhasan@gmail.com 10031947532846002269 10031947532846002269 Yes Department of surgery, School of Medicine, Babol University of Medical Sciences, Babol, Iran