en غدد بزرگسال غدد بزرگسال پژوهشی اصیل Original Article <span style="font-size:11pt"><span style="line-height:12.0pt"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><i><span chaparral="" pro="" style="font-family:"><span style="color:#003399">Background</span></span></i></b><b><span chaparral="" pro="" style="font-family:"><span style="color:#003399">:</span></span></b> <span chaparral="" pro="" style="font-family:"><span style="color:black">Hypothyroidism is associated with a wide range of physical and psychological symptoms, including anxiety and depression. However, the extent to which levothyroxine therapy improves psychological symptoms in patients with clinical hypothyroidism remains unclear. Therefore, this study aimed to evaluate changes in psychological symptoms and general health among patients with hypothyroidism treated with levothyroxine.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:12.0pt"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span chaparral="" pro="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:12.0pt"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><i><span chaparral="" pro="" style="font-family:"><span style="color:#003399">Methods</span></span></i></b><b><span chaparral="" pro="" style="font-family:"><span style="color:#003399">:</span></span></b> <span chaparral="" pro="" style="font-family:"><span style="color:black">This prospective cohort study was conducted among patients aged 20&ndash;45 years who were diagnosed with hypothyroidism and had thyroid-stimulating hormone (TSH) levels above the normal range. Participants completed the Symptom Checklist-25 (SCL-25) and the General Health Questionnaire-28 (GHQ-28) at baseline and again three months after initiating levothyroxine therapy. Data were analyzed using SPSS version 25. A two-tailed p-value < 0.05 was considered statistically significant.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:12.0pt"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><i><u><span chaparral="" pro="" style="font-family:"><span style="color:black"></span></span></u></i></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:12.0pt"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><i><span chaparral="" pro="" style="font-family:"><span style="color:#003399">Results</span></span></i></b><b><span chaparral="" pro="" style="font-family:"><span style="color:#003399">:</span></span></b> <span chaparral="" pro="" style="font-family:"><span style="color:black">Three months after treatment initiation, significant improvements were observed in SCL-25 symptom severity and GHQ-28 general health measures (P < 0.001). Significant differences were also observed in several SCL-25 domains, including anxiety, somatic complaints, depression, obsessive&ndash;compulsive symptoms, and interpersonal sensitivity (P < 0.05). These associations remained statistically significant after adjustment for potential confounders. Older age was positively associated with several psychological symptom domains, and sex differences were observed in selected domains.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:2.0pt"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span chaparral="" pro="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:12.0pt"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><i><span chaparral="" pro="" style="font-family:"><span style="color:#003399">Conclusion</span></span></i></b><b><span chaparral="" pro="" style="font-family:"><span style="color:#003399">:</span></span></b><span chaparral="" pro="" style="font-family:"><span style="color:black"> Levothyroxine therapy was associated with significant improvements in psychological symptoms and general health among patients with hypothyroidism. These findings suggest that assessment of thyroid function may be clinically relevant in individuals presenting with psychological distress.</span></span></span></span></span></span></span> hypothyroidism, levothyroxine, psychological symptoms, general health 20 27 http://crms.mubabol.ac.ir/browse.php?a_code=A-10-265-1&slc_lang=en&sid=1 Angela Hamidia angela_7633@yahoo.com 0000-0003-3113-2383 No Department of Development and Clinical Research, Shahid Yaheinejad Hospital, Babol University of Medical Sciences, Babol, Iran Golnaz Bakhshandeh golnazbakhshandeh@gmail.com 0009-0004-3381-1851 No Babol University of Medical Sciences, Babol, Iran Neda Meftah nedameftah@yahoo.com 0000-0002-3305-0966 No Department of Internal Medicine, School of Medicine,Rouhani Hospital,Babol University of Medical Sciences, Babol, Iran Mouodi Sussan sussan.mouodi@gmail.com 0000-0002-6573-8861 No Department of Development and Clinical Research, Shahid Yaheinejad Hospital, Babol University of Medical Sciences, Babol, Iran Azadeh Ramezani azadeh.ramezani@mubabol.ac.ir 0000-0002-8581-8666 Yes Department of Development and Clinical Research, Shahid Yaheinejad Hospital, Babol University of Medical Sciences, Babol, Iran