:: Volume 5, Issue 2 (12-2021) ::
NHJ 2021, 5(2): 10-19 Back to browse issues page
An overview of the influence of germinal centers on antibody production
Abstract:   (195 Views)
Secretory antibodies produced by B lymphocytes mediate humoral immunity. B-cells develop after maturation in bone marrow from stem cells to obtain the necessary properties to identify and combat against pathogens. B lymphocytes settle in peripheral lymphoid tissues to interact with foreign antigens. The activation of B cells in the peripheral lymphoid tissues lead to the proliferation, differentiation, and production of memory B cells and antibody-secreting plasma cells. The production of memory B cells requires the formation of germinal centers that act as a site for affinity maturation and B cells acquire the necessary changes to detect antigens and produce long-lived plasma cells. In this review, we will focus on related mechanisms of germinal center formation and production of antibodies.
Article number: 3
Keywords: B cell, Germinal center, Antibody, plasmacells
Full-Text [PDF 723 kb]   (61 Downloads)    
Type of Study: Review Article | Subject: ژنتیک ، بیولوژی سلولی مولکولی
Received: 2022/01/9 | Accepted: 2021/05/31 | Published: 2021/05/31

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Volume 5, Issue 2 (12-2021) Back to browse issues page