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An overview of the influence of germinal centers on antibody production
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Abolfazl Rahmani   , Masoud Baee , Maryam Rostamtabar , Fatemeh Davari , Hamid Reza Nouri * |
| Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran |
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Abstract: (1103 Views) |
| Secretory antibodies produced by B lymphocytes mediate humoral immunity. B-cells develop after maturation in bone marrow from stem cells to obtain the necessary properties to identify and combat against pathogens. B lymphocytes settle in peripheral lymphoid tissues to interact with foreign antigens. The activation of B cells in the peripheral lymphoid tissues lead to the proliferation, differentiation, and production of memory B cells and antibody-secreting plasma cells. The production of memory B cells requires the formation of germinal centers that act as a site for affinity maturation and B cells acquire the necessary changes to detect antigens and produce long-lived plasma cells. In this review, we will focus on related mechanisms of germinal center formation and production of antibodies. |
Article number: 3 |
| Keywords: B cell, Germinal center, Antibody, plasmacells |
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Full-Text [PDF 894 kb]
(557 Downloads)
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Type of Study: Review Article |
Subject:
ژنتیک ، بیولوژی سلولی مولکولی
Received: 2022/01/9 | Accepted: 2021/05/31 | Published: 2021/05/31
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