Volume 9, Issue 1 (4-2025)
CRMS 2025, 9(1): 61-69 |
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Department of Environmental Health Engineering, School of Public Health , Asieh.khalilpour@gmai.com
Abstract: (1310 Views)
Background: Due to the increasing resistance of Aspergillus species to azole drugs, the development of new antifungal agents with fewer side effects and potent activity is critical. This study evaluates the antifungal activity of indole carboxylic acid–pyridine derivatives against clinical isolates of Aspergillus.
Methods: This cross-sectional laboratory study examined the antifungal sensitivity of 100 clinical isolates of Aspergillus species using the broth microdilution method (CLSI M38-A2 protocol). The minimum inhibitory concentrations (MICs) of five derivatives (K1–K5) and itraconazole were determined visually after 48 hours of incubation at 35°C. Statistical analyses were performed using SPSS version 22, and significance was set at p < 0.05.
Results: There was no statistically significant correlation between the MIC values of the tested derivatives and itraconazole (Wilcoxon signed-rank test, p < 0.001). None of the derivatives exhibited superior antifungal effects. Itraconazole consistently demonstrated lower MICs across all Aspergillus species compared to the tested derivatives.
Conclusion: The indole carboxylic acid–pyridine derivatives exhibited significantly weaker antifungal activity compared to itraconazole. Further structural optimization is needed to improve their efficacy.
Methods: This cross-sectional laboratory study examined the antifungal sensitivity of 100 clinical isolates of Aspergillus species using the broth microdilution method (CLSI M38-A2 protocol). The minimum inhibitory concentrations (MICs) of five derivatives (K1–K5) and itraconazole were determined visually after 48 hours of incubation at 35°C. Statistical analyses were performed using SPSS version 22, and significance was set at p < 0.05.
Results: There was no statistically significant correlation between the MIC values of the tested derivatives and itraconazole (Wilcoxon signed-rank test, p < 0.001). None of the derivatives exhibited superior antifungal effects. Itraconazole consistently demonstrated lower MICs across all Aspergillus species compared to the tested derivatives.
Conclusion: The indole carboxylic acid–pyridine derivatives exhibited significantly weaker antifungal activity compared to itraconazole. Further structural optimization is needed to improve their efficacy.
Type of Study: Original Article |
Subject:
قارچ شناسی
Received: 2025/05/26 | Accepted: 2025/07/27 | Published: 2025/08/25
Received: 2025/05/26 | Accepted: 2025/07/27 | Published: 2025/08/25
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