TY - JOUR JF - crmsjournal JO - CRMS VL - 5 IS - 2 PY - 2021 Y1 - 2021/12/01 TI - An overview of the influence of germinal centers on antibody production TT - N2 - Secretory antibodies produced by B lymphocytes mediate humoral immunity. B-cells develop after maturation in bone marrow from stem cells to obtain the necessary properties to identify and combat against pathogens. B lymphocytes settle in peripheral lymphoid tissues to interact with foreign antigens. The activation of B cells in the peripheral lymphoid tissues lead to the proliferation, differentiation, and production of memory B cells and antibody-secreting plasma cells. The production of memory B cells requires the formation of germinal centers that act as a site for affinity maturation and B cells acquire the necessary changes to detect antigens and produce long-lived plasma cells. In this review, we will focus on related mechanisms of germinal center formation and production of antibodies. SP - 10 EP - 19 AU - Rahmani, Abolfazl AU - Baee, Masoud AU - Rostamtabar, Maryam AU - Davari, Fatemeh AU - Nouri, Hamid Reza AD - Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran KW - B cell KW - Germinal center KW - Antibody KW - plasmacells UR - http://crms.mubabol.ac.ir/article-1-119-en.html DO - 10.22088/crms.5.2.10 ER -