Current Research in Medical Sciences

en فرمولاسیون جدید اولئورسین زردچوبه رشد سلولی و رفتارهای مهاجرتی سلول های سرطان سینه را مهار می کند. Novel formulated form of turmeric oleoresin inhibits cell growth and migratory behaviors of breast cancer cells طب سنتی طب سنتی پژوهشی اصیل Original Article Background and Objective: Curcumin is a polyphenolic compound derived from Curcumin longa L. There is growing body of data showing the antitumor effect of curcumin in different cancers; however, its efficacy is limited by its low absorption rate. Here, we investigated the antitumor activity of turmeric oleoresin alone or in combination with paclitaxel in MCF-7 cells in monolayer cell cultures and spheroids models. Methods: The antiproliferative activities of 3 different form, curcumin, phospholipidated curcumin, and turmeric oleoresin were assessed by MTT assay. The migratory behaviors of the cells were determined by migration assay before and after treatment with curcumin. The expression levels of CyclinD1, P65, Nf-kB, and E-cadherin were studied. Findings: Curcumin suppressed cell growth in MCF-7 cells via modulation of CyclinD1 and NF-KB, which was more pronounced with turmeric oleoresin. Curcumin was able to reduce the invasiveness of MCF-7, compared to control cells through perturbation of E-cadherin. Conclusion: We demonstrated the antitumor activity of curcumin and curcumin oleoresin in breast cancer cells, supporting further investigations on the therapeutic potential of this novel anticancer agent in in vivo models.   Breast cancer, Curcumin, Anti-tumor effect, Spheroid, Oleoresin 23 31 http://crms.mubabol.ac.ir/browse.php?a_code=A-10-157-1&slc_lang=en&sid=1 Z Bahmani زاهده بهمنی z_bahmani@yahoo.com 10031947532846001688 10031947532846001688 No Department of Biochemistry, Faculty of Science, Payame Noor University, Mashhad, Iran پیام نور مشهد F Ghasemi فائزه قاسمی f.ghasemi@yahoo.com 10031947532846001689 10031947532846001689 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. مرکز تحقیقات سندرم متابولیک Gh Pourali غزاله پورعلی PouraliGh2@mums.ac.ir 10031947532846001690 10031947532846001690 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. مرکز تحقیقات سندرم متابولیک Sh Mehrabadi شیما مهرآبادی sh-mehrabadi@razi.tums.ac.ir 10031947532846001691 10031947532846001691 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. مرکز تحقیقات سندرم متابولیک S M Hassanian سید مهدی حسنیان HasanianMehrM@mums.ac.ir 10031947532846001692 10031947532846001692 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. مرکز تحقیقات سندرم متابولیک S ShahidSales سودابه شهیدثالث S.Shahid335@yahoo.com 10031947532846001693 10031947532846001693 No Cancer Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran مرکز تحقیقات سرطان علوم پزشکی مشهد M Saleh Moghaddam مسعود صالح مقدم SalehM@yahoo.com 10031947532846001694 10031947532846001694 No Department of Biochemistry, Faculty of Science, Payame Noor University, Mashhad, Iran پیام نور مشهد S Ebrahimi صفیه ابراهیمی S.ebrahimi2@mums.ac.ir 10031947532846001695 10031947532846001695 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. مرکز تحقیقات سندرم متابولیک A Sahebkar امیر حسین صاحبکار Sahebkar@mums.ac.ir 10031947532846001696 10031947532846001696 No Basic Sciences Research Institute, Mashhad University of Medical Science, Mashhad, Iran. مرکز تحقیقات علوم پایه، علوم پزشکی مشهد A Avan امیر آوان amir_avan200@yahoo.com 10031947532846001697 10031947532846001697 Yes Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran مرکز تحقیقات سندرم متابولیک