Current Research in Medical Sciences

en The effect of hydroxychloroquine in COVID-19 patients who did not receive corticosteroids عفونی ، اطفال عفونی ، اطفال پژوهشی اصیل Original Article Background and Objective: At the beginning of the pandemic, Hydroxychloroquine (HCQ) was one of the most widely used drugs prescribed to patients admitted to hospitals with coronavirus disease 2019 (COVID-19). We try to find the effect of HCQ on the severity and mortality of patients who did not receive corticosteroids. Methods: In this retrospective study, patients with COVID-19 disease were collected from February 20, 2020, to July 21, 2020, at Rouhani Hospital in Babol. Patients were followed up until December 6, 2021. In this study, 170 patients in case and control groups were studied. We used logistic and COX regression models to explore the effects of drugs. Data were analyzed by SPSS version 22. Findings: The use of HCQ did not affect mortality (p=0. 46, 95%CI= 0.63 to 2.71, OR= 1.31) and final severity (p= 0.75, 95%CI= 0.59 to 2.06, OR= 1.10) at admission time. However, azithromycin remained in the final model but did not have a significant effect (P= 0.08, HR= 0.28, 95%CI= 0.06 to 0.18). Heparin use was not associated with severity improvement (p= 0.06, 95%CI= 0.97 to 2.81, HR= 1.65), while ceftriaxone remained a factor affecting severity in the model (p = 0.03, 95% CI= 0.29 to 0.95, HR = 0.52). Conclusion: In this study, HCQ harmed mortality admission time and was ineffective in the long term. The use of ceftriaxone compared to other drugs showed protective effects against the mortality hospitalization time. Heparin is not recommended without considering the risk of bleeding in COVID-19 patients.   COVID-19, HCQ, Hydroxychloroquine, Mortality, Coronavirus 48 57 http://crms.mubabol.ac.ir/browse.php?a_code=A-10-169-1&slc_lang=en&sid=1 P Ebrahimi pouyanebi1375@gmail.com 10031947532846001765 10031947532846001765 No Student Research Committee, Babol University of Medical Science, Babol, Iran A Zabihzade azadehzabihzade@gmail.com 10031947532846001766 10031947532846001766 No Student Research Committee, Babol University of Medical Science, Babol, Iran N Khodadad nimakhodadadian@gmail.com 10031947532846001767 10031947532846001767 No Student Research Committee, Babol University of Medical Science, Babol, Iran H Shirafkan hodashirafkan2@gmail.com 10031947532846001768 10031947532846001768 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran M Sadeghi mahmoudsadeghi1975@gmail.com 10031947532846001769 10031947532846001769 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran S H Abedi h.abedi@doctor.com 10031947532846001770 10031947532846001770 Yes Department of Internal Medicine, School of Medicine, Babol University of Medical Sciences, Babol, I.R Iran