Current Research in Medical Sciences

en Comparing Bowel Preparation Quality in Chronic Kidney Disease Patients: Low-Dose Polyethylene Glycol (PEG) vs. Low-Dose PEG with SenaGraph اورولوژی اورولوژی پژوهشی اصیل Original Article Background: Renal failure presents a critical concern in patients requiring colon preparation for colonoscopy, particularly in those with chronic kidney disease (CKD). In contemporary practice, polyethylene glycol (PEG) serves as a widely employed agent, while herbal alternatives like Sena<a name="_Hlk145568198">Graph, standardized dry extract of Senna leaves (Cassia angustifolia L.), </a>have demonstrated satisfactory efficacy. This study aimed to compare the quality of bowel preparation in CKD patients using low-dose PEG with and without Sena Graph. Methods: This randomized clinical trial enrolled 122 patients with CKD who underwent colonoscopies at Imam Hussein Hospital in Tehran, Iran, during 2018 and 2019. Patients were randomly assigned to receive either PEG with SenaGraph or PEG alone. Comparative assessments included the Ottawa Score and measurements of sodium, potassium, urea, and creatinine levels. Results: The study findings revealed that the mean Ottawa score was deemed acceptable (Ottawa score 0 or 1) in 90.2% of patients receiving PEG with SenaGraph and in 78.7% of patients in the PEG-only group, with statistically significant difference (P = 0.049). Alterations in sodium, potassium, urea, and creatinine levels showed no significant differences between the two groups (P > 0.05). Conclusion: This investigation suggests that, in CKD patients requiring colonoscopy, the addition of Sena Graph to PEG could improve the efficacy of PEG. Furthermore, both agents exhibit a comparable safety profile for bowel preparation.   PEG, Sena grafin, CKD, Colonoscopy 21 28 http://crms.mubabol.ac.ir/browse.php?a_code=A-10-213-1&slc_lang=en&sid=1 Majid Iranshahi Iranshahi.majid@yahoo.com 10031947532846002075 10031947532846002075 No Imam Hossein Hospital, Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Tahereh Sabaghian ph.sabaghian@sbmu.ac.ir 10031947532846002076 10031947532846002076 No Department of Internal Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Farzaneh Tolouei f.tolouei87@gmail.com 10031947532846002077 10031947532846002077 Yes . Imam Hossein Hospital, Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.