Current Research in Medical Sciences

en A Cross-Sectional Comparative Study of Methadone Dosage in Adults with and Without ADHD Symptoms under Maintenance Therapy روانپزشکی روانپزشکی پژوهشی اصیل Original Article Background: ADHD often continues into adulthood and can be difficult to manage effectively. For opioid use disorder, methadone is regarded as the first-line treatment option. This study aims to compare methadone dosage in patients undergoing maintenance therapy, with and without symptoms of ADHD. Methods: This cross-sectional study involved 230 patients receiving methadone maintenance therapy at Shahid Zakarian Health Center in Babol during 2023-2024. ADHD diagnoses were established using the ASRS-v1.1 questionnaire. Data were analyzed using SPSS software, with significance level under 0.05. Specifically, linear regression models were used to explore associations between methadone dosage and ADHD symptoms. Results: Out of 230 patients, 80 (34.79%) exhibited symptoms of ADHD. The average age of these patients was 43.91 years, with the majority being under 30 years old and unmarried. There was no statistically significant difference in methadone dosage between patients with ADHD symptoms (68.38 mg) and those without (69.73 mg) (P = 0.771). There was a weak, non-significant correlation between ASRS scores and methadone dosage (r = -0.063, P = 0.344). Additionally, none of the demographic variables such as gender (with B Coefficient = 5.85 for females), marital status (B Coefficient = 8.37 for married individuals), or education level (B Coefficient = 2.59 for those with lower education) were significant predictors of methadone dosage. Conclusion: Methadone dosage in patients with ADHD symptoms did not significantly differ from those without symptoms and was not influenced by demographic variables. However, early screening and individualized dosage adjustments for patients with ADHD, particularly men, married individuals, and those with lower education levels, are recommended. Attention Deficit Disorder with Hyperactivity, Methadone, Attention Deficit Disorder, ADHD, Maintenance. 21 31 http://crms.mubabol.ac.ir/browse.php?a_code=A-10-259-1&slc_lang=en&sid=1 Shayan Beyrami Khajeh bahramishayan27@gmail.com 10031947532846002499 10031947532846002499 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Mahjoobeh Betyar Dr.mbetyar@gmail.com 10031947532846002500 10031947532846002500 No Assistant Professor of Psychiatry, Social Determinants of Health Research Center, Health Research Institute, Babol, Iran Armon Massoodi armonmassodi2@gmail.com 10031947532846002501 10031947532846002501 Yes Assistant Professor of child and adolescent Psychiatry, Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Hemmat Gholinia Ahangar h_gholinia@yahoo.com 10031947532846002502 10031947532846002502 No Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Somayyeh Hasannattaj solhdar nattajjj.sss@gmail.com 10031947532846002503 10031947532846002503 No Babol University of Medical Sciences, Babol, Iran