Abstract: Today, cancer remains a worldwide and severe public health challenge. Cancer is one of the reasons of disease and mortality global; chiefly owing to problems in treatment-associated, recurrence rates, metastasis and late diagnosis. In latest years, with the development of nano-materials, the investigation of drug delivery systems has become a novel field of cancer therapy. Local drug delivery systems are hopeful apparatuses in modern medicine because they can promise the release of drugs with the kinetics necessary; via specific applications and a reduction in unwanted side effects. Drug delivery systems are typically composed of delivery carriers, antitumor drugs, and even target molecules. Over the years, a wide variation of polymeric nano-mats has been explored as implantable single drug delivery systems. Gelatin is a natural polymer with highly biocompatibility and non-toxicity that is manufactured via thermal denaturalization of collagen, which is available in animal skin and bones in the presence of dilute acids. On the other hand, electrospinning is a widely considered method for the progress of drug-delivery nano-mats. 3-D Gelatin electrospun nanofibers (with great porosity and small pore size) can be applied to deliver anti-cancer drugs (like Doxorubicin, Tamoxifen and Curcumin) in cancer therapy. This mini review presents the gelatin nanofibrous anti-cancer drug delivery carriers for clinical application of cancer nanomedicine in the future.