Unraveling the multifaceted molecular interactions of HPV E6 in carcinogenesis

Letafati, Arash; Salahi, Omid; Jazayeri, Seyed Mohammad; Ghaziasadi, Azam; Sakhavarz, Tannaz; Soleimani, Mina; Goldoost, Yeganeh; Norouzi, Mehdi

doi:10.22088/crms.7.2.58

Volume 7, Issue 2 (9-2023) CRMS 2023, 7(2): 58-70 | Back to browse issues page

‎ 10.22088/crms.7.2.58

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Letafati A, Salahi O, Jazayeri S M, Ghaziasadi A, Sakhavarz T, Soleimani M, et al . Unraveling the multifaceted molecular interactions of HPV E6 in carcinogenesis. CRMS 2023; 7 (2) :58-70
URL: http://crms.mubabol.ac.ir/article-1-155-en.html

Unraveling the multifaceted molecular interactions of HPV E6 in carcinogenesis

Arash Letafati

, Omid Salahi

, Seyed Mohammad Jazayeri

, Mehdi Norouzi ^*

Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran. , mnorouzi@tums.ac.ir

Abstract: (2446 Views)

Background: Human Papillomaviruses (HPVs) are common sexually transmitted viruses that cause health problems, including genital warts and different type of cancers. There are over 200 different types of HPV, some of which are correlated with the progress of cervical cancer. One of the HPV genes responsible for its oncogenic potential is the E6 gene. E6 is a critical protein in the life cycle of HPV and a key contributor to the development of HPV-associated cancers. Its interactions with cellular proteins lead to disruptions in key cellular pathways and the promotion of cancerous cell growth. Overall, HPV E6 represents a reassuring target for the expansion of novel therapies for the treatment of HPV-associated cancers and understanding its molecular interactions with host proteins is critical for developing targeted therapies for HPV-associated cancers. In this article, we will focus on the cancer-related mechanism and cell interaction of HPV E6.

Keywords: Cancer, Viruses, Tumor suppressors, HPV, Cervical cancer, HPV E6

Full-Text [PDF 645 kb] (1180 Downloads)

Type of Study: Review Article | Subject: ویروس شناسی
Received: 2023/06/13 | Accepted: 2023/10/15 | Published: 2023/10/21