دوره 9، شماره 1 - ( 2-1404 )
جلد 9 شماره 1 صفحات 109-98 |
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Mohseni Afshar Z, Fili R, Behmanesh F. The Detrimental Impact of Dysbiosis in Gynecology and Obstetrics, Alongside the Positive Role of Probiotics in Prevention and Treatment: A Review Article. CRMS 2025; 9 (1) :98-109
URL: http://crms.mubabol.ac.ir/article-1-210-fa.html
URL: http://crms.mubabol.ac.ir/article-1-210-fa.html
The Detrimental Impact of Dysbiosis in Gynecology and Obstetrics, Alongside the Positive Role of Probiotics in Prevention and Treatment: A Review Article. Current Research in Medical Sciences. 1404; 9 (1) :98-109
چکیده: (333 مشاهده)
Reproductive tract microbiome dysbiosis contributes to various gynecological and obstetric issues, including vaginal infections, adverse pregnancy outcomes, endometriosis, pelvic pain, sexually transmitted diseases, vulvodynia, and pelvic organ prolapse. Probiotics offer a promising approach to mitigating these problems through mechanisms such as microbiome regulation, immune system strengthening, antioxidant effects, and production of anti-mutagenic compounds. Common probiotics used to modulate reproductive dysbiosis include: Limosilactobacillus reuteri RC-14, L. fermentum, L. gasseri, L. rhamnosus, L. acidophilus, L. crispatus, L. casei, L. salivarius. Given the increasing prevalence of antibiotic resistance and associated limitations, probiotics represent a valuable therapeutic strategy; however, further research is required to optimize strain selection and dosage for specific conditions. Investigations should consider diverse populations, varying dosages, and different routes of administration (e.g., oral vs. vaginal suppositories) to determine the optimal approach for maximizing therapeutic benefits. The aim of the this study is to review the detrimental impact of reproductive tract microbiome dysbiosis on various gynecological and obstetric conditions, while also exploring the positive role that probiotics may play in the prevention and treatment of these conditions. The review seeks to evaluate how dysbiosis contributes to vaginal infections, adverse pregnancy outcomes, endometriosis, pelvic pain, sexually transmitted diseases, vulvodynia, and pelvic organ prolapse, as well as to assess the mechanisms through which probiotics may mitigate these problems, including microbiome regulation, immune system strengthening, antioxidant effects, and production of anti-mutagenic compounds.
نوع مطالعه: مروری |
موضوع مقاله:
میکروبیولوژی
دریافت: 1404/4/21 | پذیرش: 1404/7/20 | انتشار: 1404/9/8
دریافت: 1404/4/21 | پذیرش: 1404/7/20 | انتشار: 1404/9/8
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