Current Research in Medical Sciences
Babol Univesity of Medical Sciences
Mon, Jun 8, 2026
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Volume 9, Issue 2 (2-2025)
CRMS 2025, 9(2): 24-29 |
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Khosravi S, Mahmoodi M, Vakili Sadeghi M, Gholinia H, Majid Nabipuor M. Effectiveness of Oral Iron Supplementation on Hemoglobin in Non-Anemic Women with Serum Ferritin Levels of 15 to 50 Micrograms/Liter. CRMS 2025; 9 (2) : 4
URL: http://crms.mubabol.ac.ir/article-1-216-en.html
URL: http://crms.mubabol.ac.ir/article-1-216-en.html
Sahar Khosravi 
, Mahboobeh Mahmoodi , Mohsen Vakili Sadeghi * , Hemmat Gholinia , Majid Majid Nabipuor
, Mahboobeh Mahmoodi , Mohsen Vakili Sadeghi * , Hemmat Gholinia , Majid Majid Nabipuor
Associate Professor of Hematology & Oncology, Cancer Research Center, Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran. , mvakili89@gmail.com
Abstract: (17 Views)
Background: According to medical resources, iron deficiency anemia occurs after the depletion of iron stores when ferritin levels reach 15 micrograms per liter (μg/L) or less. However, clinical experiences show different results. This study aimed to determine the effectiveness of oral iron supplementation on hemoglobin levels in non-anemic women with serum ferritin levels of 15–50 μg/L.
Methods: Women aged 18 to 60 years with complaints of fatigue and/or anemia, hemoglobin above 12 grams per deciliter (g/dL) or above 11 g/dL with thalassemia minor characteristics, and ferritin levels of 15 to 50 μg/L were included. Participants were not pregnant and had no underlying acute or chronic disease. Those who did not take iron supplements regularly or did not attend a second appointment were excluded. Patients were treated with a daily oral ferrous sulfate iron supplement containing 50–100 milligrams (mg) of elemental iron for at least six weeks. Laboratory data were compared before and after treatment
Results: Fifty-two females with a mean age of 40.23 ± 16.31 years were included. The mean hemoglobin level before treatment was 12.40 ± 1.08 g/dL, increasing to 13.04 ± 1.04 g/dL after treatment (P < 0.001). The mean serum ferritin level increased from 27.51 μg/L before treatment to 51.81 μg/L after treatment (P < 0.001). Hemoglobin increments were also observed in two subgroups: those with ferritin levels of 15–30 μg/L (P < 0.001) and those with levels of 30–50 μg/L (P = 0.001).
Conclusion: Oral iron supplementation increases hemoglobin levels in non-anemic women with serum ferritin levels of 15–50 μg/L. It is advisable to consider ferritin levels below 50 μg/L as an indicator of depletion of iron body stores.
Methods: Women aged 18 to 60 years with complaints of fatigue and/or anemia, hemoglobin above 12 grams per deciliter (g/dL) or above 11 g/dL with thalassemia minor characteristics, and ferritin levels of 15 to 50 μg/L were included. Participants were not pregnant and had no underlying acute or chronic disease. Those who did not take iron supplements regularly or did not attend a second appointment were excluded. Patients were treated with a daily oral ferrous sulfate iron supplement containing 50–100 milligrams (mg) of elemental iron for at least six weeks. Laboratory data were compared before and after treatment
Results: Fifty-two females with a mean age of 40.23 ± 16.31 years were included. The mean hemoglobin level before treatment was 12.40 ± 1.08 g/dL, increasing to 13.04 ± 1.04 g/dL after treatment (P < 0.001). The mean serum ferritin level increased from 27.51 μg/L before treatment to 51.81 μg/L after treatment (P < 0.001). Hemoglobin increments were also observed in two subgroups: those with ferritin levels of 15–30 μg/L (P < 0.001) and those with levels of 30–50 μg/L (P = 0.001).
Conclusion: Oral iron supplementation increases hemoglobin levels in non-anemic women with serum ferritin levels of 15–50 μg/L. It is advisable to consider ferritin levels below 50 μg/L as an indicator of depletion of iron body stores.
Article number: 4
Type of Study: Original Article |
Subject:
هماتولوژی
Received: 2025/09/22 | Accepted: 2026/06/6 | Published: 2026/06/6
Received: 2025/09/22 | Accepted: 2026/06/6 | Published: 2026/06/6
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