Current Research in Medical Sciences
Babol Univesity of Medical Sciences
Mon, Oct 12, 2026
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Volume 9, Issue 2 (2-2025)
CRMS 2025, 9(2): 75-80 |
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Mir M, Yari M, Seyfi S. Comparison of Cold Normal Saline and Lidocaine for Pain Relief During Propofol Injection. CRMS 2025; 9 (2) : 10
URL: http://crms.mubabol.ac.ir/article-1-207-en.html
URL: http://crms.mubabol.ac.ir/article-1-207-en.html
Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran & Associate Professor of Critical Care Medicine, Clinical research development unit of Rouhani hospital, Babol University of Medical Sciences Babol, Iran. , ficu_ss@yahoo.com
Abstract: (12 Views)
Background: Propofol is a commonly used anesthetic agent that frequently causes severe pain upon injection. Various pharmacological and non-pharmacological interventions have been employed to reduce the severity of this injection-related pain. The aim of this study was to compare the efficacy of intravenous cold normal saline with that of lidocaine in reducing pain during propofol injection.
Methods: Patients were randomly assigned to three groups of 40 using permuted block randomization. Each patient received one of the following interventions: Group A received intravenous (IV) cold normal saline (4°C); Group B received IV room-temperature normal saline (25°C); and Group C (control group) received IV lidocaine 0.5%. All groups subsequently received 50 mg of 1% propofol. Pain intensity was assessed using a visual analog scale (VAS) at baseline, and at 15 and 30 seconds after propofol injection. Heart rate and blood pressure were recorded before injection and continued for up to 15 minutes after drug administration. Data were presented as mean ± standard deviation (SD), and a P-value < 0.05 was considered statistically significant. All statistical analyses were performed using GraphPad Prism version 8.0.
Results: Pain intensity in patients receiving cold saline was lower than that in the other two groups; however, this difference did not reach statistical significance. Heart rate and blood pressure values remained within normal physiological ranges across all groups throughout the study period.
Conclusion: Cold normal saline may serve as a suitable and cost-effective alternative to lidocaine for reducing pain during propofol injection, given its comparable analgesic efficacy (p = 0.12).
Methods: Patients were randomly assigned to three groups of 40 using permuted block randomization. Each patient received one of the following interventions: Group A received intravenous (IV) cold normal saline (4°C); Group B received IV room-temperature normal saline (25°C); and Group C (control group) received IV lidocaine 0.5%. All groups subsequently received 50 mg of 1% propofol. Pain intensity was assessed using a visual analog scale (VAS) at baseline, and at 15 and 30 seconds after propofol injection. Heart rate and blood pressure were recorded before injection and continued for up to 15 minutes after drug administration. Data were presented as mean ± standard deviation (SD), and a P-value < 0.05 was considered statistically significant. All statistical analyses were performed using GraphPad Prism version 8.0.
Results: Pain intensity in patients receiving cold saline was lower than that in the other two groups; however, this difference did not reach statistical significance. Heart rate and blood pressure values remained within normal physiological ranges across all groups throughout the study period.
Conclusion: Cold normal saline may serve as a suitable and cost-effective alternative to lidocaine for reducing pain during propofol injection, given its comparable analgesic efficacy (p = 0.12).
Article number: 10
Type of Study: Original Article |
Subject:
داخلی
Received: 2025/06/15 | Accepted: 2025/12/21 | Published: 2026/10/11
Received: 2025/06/15 | Accepted: 2025/12/21 | Published: 2026/10/11
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