An overview of the influence of germinal centers on antibody production

Rahmani, Abolfazl; Baee, Masoud; Rostamtabar, Maryam; Davari, Fatemeh; Nouri, Hamid Reza

doi:10.22088/crms.5.2.10

Volume 5, Issue 2 (12-2021) CRMS 2021, 5(2): 10-19 | Back to browse issues page

‎ 10.22088/crms.5.2.10

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Rahmani A, Baee M, Rostamtabar M, Davari F, Nouri H R. An overview of the influence of germinal centers on antibody production. CRMS 2021; 5 (2) : 3
URL: http://crms.mubabol.ac.ir/article-1-119-en.html

An overview of the influence of germinal centers on antibody production

Abolfazl Rahmani

, Masoud Baee

, Maryam Rostamtabar

, Fatemeh Davari

, Hamid Reza Nouri ^*

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Abstract: (2532 Views)

Secretory antibodies produced by B lymphocytes mediate humoral immunity. B-cells develop after maturation in bone marrow from stem cells to obtain the necessary properties to identify and combat against pathogens. B lymphocytes settle in peripheral lymphoid tissues to interact with foreign antigens. The activation of B cells in the peripheral lymphoid tissues lead to the proliferation, differentiation, and production of memory B cells and antibody-secreting plasma cells. The production of memory B cells requires the formation of germinal centers that act as a site for affinity maturation and B cells acquire the necessary changes to detect antigens and produce long-lived plasma cells. In this review, we will focus on related mechanisms of germinal center formation and production of antibodies.

Article number: 3

Keywords: B cell, Germinal center, Antibody, plasmacells

Full-Text [PDF 894 kb] (1492 Downloads)

Type of Study: Review Article | Subject: ژنتیک ، بیولوژی سلولی مولکولی
Received: 2022/01/9 | Accepted: 2021/05/31 | Published: 2021/05/31