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An overview of the influence of germinal centers on antibody production
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چکیده: (1106 مشاهده) |
| Secretory antibodies produced by B lymphocytes mediate humoral immunity. B-cells develop after maturation in bone marrow from stem cells to obtain the necessary properties to identify and combat against pathogens. B lymphocytes settle in peripheral lymphoid tissues to interact with foreign antigens. The activation of B cells in the peripheral lymphoid tissues lead to the proliferation, differentiation, and production of memory B cells and antibody-secreting plasma cells. The production of memory B cells requires the formation of germinal centers that act as a site for affinity maturation and B cells acquire the necessary changes to detect antigens and produce long-lived plasma cells. In this review, we will focus on related mechanisms of germinal center formation and production of antibodies. |
شمارهی مقاله: 3 |
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نوع مطالعه: مروری |
موضوع مقاله:
ژنتیک ، بیولوژی سلولی مولکولی
دریافت: 1400/10/19 | پذیرش: 1400/3/10 | انتشار: 1400/3/10
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