دوره 5، شماره 2 - ( 10-1400 )
جلد 5 شماره 2 صفحات 19-10 |
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Rahmani A, Baee M, Rostamtabar M, Davari F, Nouri H R. An overview of the influence of germinal centers on antibody production. CRMS 2021; 5 (2) : 3
URL: http://crms.mubabol.ac.ir/article-1-119-fa.html
URL: http://crms.mubabol.ac.ir/article-1-119-fa.html
An overview of the influence of germinal centers on antibody production. Current Research in Medical Sciences. 1400; 5 (2) :10-19
چکیده: (2607 مشاهده)
Secretory antibodies produced by B lymphocytes mediate humoral immunity. B-cells develop after maturation in bone marrow from stem cells to obtain the necessary properties to identify and combat against pathogens. B lymphocytes settle in peripheral lymphoid tissues to interact with foreign antigens. The activation of B cells in the peripheral lymphoid tissues lead to the proliferation, differentiation, and production of memory B cells and antibody-secreting plasma cells. The production of memory B cells requires the formation of germinal centers that act as a site for affinity maturation and B cells acquire the necessary changes to detect antigens and produce long-lived plasma cells. In this review, we will focus on related mechanisms of germinal center formation and production of antibodies.
شمارهی مقاله: 3
نوع مطالعه: مروری |
موضوع مقاله:
ژنتیک ، بیولوژی سلولی مولکولی
دریافت: 1400/10/19 | پذیرش: 1400/3/10 | انتشار: 1400/3/10
دریافت: 1400/10/19 | پذیرش: 1400/3/10 | انتشار: 1400/3/10
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