Current Research in Medical Sciences
Babol Univesity of Medical Sciences
Tue, Jun 23, 2026
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Volume 9, Issue 2 (2-2025)
CRMS 2025, 9(2): 30-37 |
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Mohseni S M, Ebrahimpour S, Barary M, Faghanzadeh Ganji G, Babazadeh A, Amin K, et al . Association Between Influenza-like Illness and Acute Myocardial Infarction: A Case-control Study. CRMS 2025; 9 (2) : 5
URL: http://crms.mubabol.ac.ir/article-1-215-en.html
URL: http://crms.mubabol.ac.ir/article-1-215-en.html
Seyed Morteza Mohseni 
, Soheil Ebrahimpour , Mohammad Barary , Ghasem Faghanzadeh Ganji , Arefeh Babazadeh , Kamyar Amin , Ali Tavakoli Pirzaman , Malihe Esmailzadeh , Hossein Nazari Rostami , Mehran Shokri *
, Soheil Ebrahimpour , Mohammad Barary , Ghasem Faghanzadeh Ganji , Arefeh Babazadeh , Kamyar Amin , Ali Tavakoli Pirzaman , Malihe Esmailzadeh , Hossein Nazari Rostami , Mehran Shokri *
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran , mh.shokri90@gmail.com
Abstract: (18 Views)
Background: Acute myocardial infarction (AMI) is a leading cause of death worldwide. Seasonal influenza can lead to cardiovascular complications. Thus, the association between influenza and cardiovascular events has recently attracted considerable interest. This study aimed to investigate recent influenza-like illness (ILI) among AMI patients compared with other hospitalized patients (control group) during the cold season in northern Iran.
Methods: This retrospective case-control study included 300 patients (150 AMI patients and 150 controls) aged ≥ 50 years who were hospitalized for AMI or other conditions between September 22, 2019, and March 15, 2020. Patients in each group were frequency-matched for gender and age range. The primary exposure was recent ILI (fever ≥ 37.8°C, cough, and sore throat) during the past month.
Results: Fifty-two females with a mean age of 40.23 ± 16.31 years were included. The mean hemoglobin level before treatment was 12.40 ± 1.08 g/dL, increasing to 13.04 ± 1.04 g/dL after treatment (p < 0.001). The mean serum ferritin level increased from 27.51 μg/L before treatment to 51.81 μg/L after treatment (p < 0.001). Hemoglobin increments were also observed in two subgroups: those with ferritin levels of 15–30 μg/L (p < 0.001) and those with levels of 30–50 μg/L (p = 0.001).
Conclusion: The patients’ mean age was 64.42 ± 9.47 years, ranging from 50 to 94 years. Overall, 150 (50%) patients reported ILI, with a significantly higher prevalence in the AMI group (111 cases, 74%) than in controls (39 cases, 26%). Patients in the AMI group reported ILI significantly more often than controls (adjusted OR: 3.04, 95% CI: 1.02-9.09, p < 0.001). On the other hand, patients who received the influenza vaccine were significantly less likely to have an acute myocardial infarction than those who did not (adjusted OR: 0.02, 95% CI: 0.001-0.38, p = 0.006).
Methods: This retrospective case-control study included 300 patients (150 AMI patients and 150 controls) aged ≥ 50 years who were hospitalized for AMI or other conditions between September 22, 2019, and March 15, 2020. Patients in each group were frequency-matched for gender and age range. The primary exposure was recent ILI (fever ≥ 37.8°C, cough, and sore throat) during the past month.
Results: Fifty-two females with a mean age of 40.23 ± 16.31 years were included. The mean hemoglobin level before treatment was 12.40 ± 1.08 g/dL, increasing to 13.04 ± 1.04 g/dL after treatment (p < 0.001). The mean serum ferritin level increased from 27.51 μg/L before treatment to 51.81 μg/L after treatment (p < 0.001). Hemoglobin increments were also observed in two subgroups: those with ferritin levels of 15–30 μg/L (p < 0.001) and those with levels of 30–50 μg/L (p = 0.001).
Conclusion: The patients’ mean age was 64.42 ± 9.47 years, ranging from 50 to 94 years. Overall, 150 (50%) patients reported ILI, with a significantly higher prevalence in the AMI group (111 cases, 74%) than in controls (39 cases, 26%). Patients in the AMI group reported ILI significantly more often than controls (adjusted OR: 3.04, 95% CI: 1.02-9.09, p < 0.001). On the other hand, patients who received the influenza vaccine were significantly less likely to have an acute myocardial infarction than those who did not (adjusted OR: 0.02, 95% CI: 0.001-0.38, p = 0.006).
Article number: 5
Type of Study: Original Article |
Subject:
بیماری های عفونی
Received: 2025/09/10 | Accepted: 2025/12/31 | Published: 2026/06/22
Received: 2025/09/10 | Accepted: 2025/12/31 | Published: 2026/06/22
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